Comparative Evaluation of Analgesic, Antipyretic & Anti-Inflammatory Effects of Various Extracts of Dried Fruit of Illicium verum Hook.f (Star anise) in Rodents

The current investigation was designed to evaluate the analgesic, antipyretic, and anti-inflammatory effects of various extracts (methanol, ethanol, aqueous) dried fruit Illicium verum hook.f, using 3 different doses (150, 250, 350 mg/kg p.o) verify traditional uses this spice. In hot plate model analgesia, ethanol extract showed a significant reduction in pain dose-dependent manner compared control group. maximum effect observed at dosage i.e., 16.90±0.17 s group 5.03±0.05 s. antipyretic activity assessed rats by Brewer’s yeast induction. methanol produced rectal temperature throughout three doses. 37.1±0.8* 39.1±0.3. paw edema model, disclosed dose. 0.25±0.23* 0.97±0.4. behavioral study, locomotor (rearing) exploratory (grooming) mice reduced significantly higher (350 involving extracts. However, scratching increased non-significantly all This study concluded that hook.f with varying potencies. found be more potent among all, followed aqueous extracts, whereas were